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Suday, Sptem er 0, 2018 PURPOSE: Current dermal replacement products perform sub-optimally in complex wound beds, such as those that have been irradiated or those with exposed hardware, mostly as a result of insufficient cell invasion and vascularization. Angiogenesis is the result of multi-step processes which involve complex interactions between endothelial cells and their microenvironment. Cells sense the rigidity of their environment in a process called mechanotransduction, which is effected through integrin-mediated adhesions. Directional cell migration based upon substrate rigidity has previously been observed in a process termed durotaxis. We have fabricated a novel micropatterned microsphere scaffold (MSS) composed of differential densities of type I collagen in order to harness these signaling cues and promote rapid cell invasion and vascularization. Herein we compare the performance of MSS to a widely utilized, commercially available dermal replacement product (Integra®) in vitro and in vivo.

Abstract: Minimizing Engineered Auricular Cartilage Contracture By Maximizing Construct/Cage Contact: The Importance of Injection Molding