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PURPOSE: Visual impairment and blindness present significant economic, social and personal burdens for millions of patients and caregivers around the world. Whole eye transplantation (WET) is a potential solution. Our lab has established a viable rodent model with promising results in syngeneic transplants. To investigate allotransplantation, successful immunosuppression is necessary. Tacrolimus monotherapy is successful in rodent VCA and has possible neuroprotective effects in the central nervous system and injured optic nerve, but its efficacy in WET is unknown. Here, we present survival of allograft WET treated with Tacrolimus monotherapy.

Abstract: Study of Retinochoroidal Circulation with Fluorescein Angiography after Whole Eye Transplantation in Rodents