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wGRS is not higher in individuals with diseases known to be associated with CTS suggests that extraneous factors (such as oedema in hypothyroidism and synovitis in rheumatoid arthritis), rather than shared genetic factors, are likely to predispose to CTS in these groups. The negative correlation between wGRS and height explains the observation that CTS patients are on average >2cm shorter than non-CTS controls in the UK Biobank cohort. We are currently extending the wGRS to our own cohort of deeply phenotyped CTS patients, to correlate wGRS with symptoms and electrophysiological test severity, as well as surgical outcomes. We believe it is important for plastic surgeons to be mindful of the increasing role that genetics will play in our practice, and this study illustrates the proof of principle that a wGRS can potentially serve as useful tool in the future for the prognostication of CTS.

Abstract: A Comparative Health Literacy Analysis of Online Carpal Tunnel Syndrome Resources Available in English and Spanish