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Skin infections due to bacteria represent significant morbidity and mortality in healthcare. Staphylococcus aureus (SA) is of particular importance because it is the most commonly isolated pathogen in surgical site infections, diabetic foot ulcers, and chronic wounds. The current treatment for skin infections ranges from empiric antibiotic therapy to aggressive surgical debridement. Mild hyperthermia, defined as temperatures less than 42°C, has been show to enhance antimicrobial activity and represents a new approach for the treatment of local infections. 3 The aim of this study was to investigate whether novel polymer nanoparticles, capable of producing localized mild hyperthermia when exposed to infrared light, can be used to more effectively treat infectious skin lesions while sparing the surrounding healthy tissue.

Abstract: The Use of Fluorescent and Heat Generating Polymer Nanoparticles As a Novel Treatment for S. Aureus Skin Lesions