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PURPOSE: Peripheral nerve injuries are common and have debilitating effects, including loss of nerve and muscle function, painful neuropathies, and impaired sensation. Current therapies do not address a major challenge of peripheral nerve regeneration: the atrophy or loss of Schwann cells (SC), which are the principal glia cell that support peripheral neurons. Recent interest in peripheral nerve regeneration has focused on using stem-cell derived SC for cellular replacement therapy. Mesenchymal stem cells, including adipose and bone marrow, have been proposed to be a good source of SC. However, bone marrow biopsies are invasive, and adipose-derived stem cells have been shown to rapidly dedifferentiate in the absence of stimulating media. Consequently, there is a pressing need to identify alternative mesenchymal stem cell sources for SC cellular replacement therapy to improve peripheral nerve regeneration. The purpose of this study was to assess the impact of musclederived stem cells (MDSCs) in augmenting nerve regeneration and improving muscle function after nerve trauma.

Abstract QS47: Wide Propeller Posterior Thigh Flap to Reconstruct Perineal Defects post Abdominoperineal Resection