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PURPOSE: Current dermal replacement products perform sub-optimally in complex wound beds, such as those that have been irradiated or those with exposed hardware, mostly as a result of insufficient cell invasion and vascularization. We have previously observed more robust endothelial cell invasion of scaffolds containing a micropatterned matrix of differential collagen stiffness in a murine model when compared to collagen controls. Herein we compare the performance of our micropatterned microsphere hydrogels (MSS) to a widely utilized commercially available dermal replacement product in vitro and in vivo.

Abstract QS31: Micropatterned Microsphere Scaffolds: Optimizing the Performance of Engineered Dermal Substitutes