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PURPOSE: Wound healing is a complex process, which is classically divided into inflammation, proliferation and remodeling phases. Macrophages play a key role in wound healing. M1 macrophages mediate tissue damage and initiate the inflammatory response in the early stages of wound healing. M2 phenotype promotes wound healing via formation of a highly vascularized, cellular granulation tissue and scar tissues. The phenotype of polarized M1-M2 macrophage can, to some extent, be reversed in vitro and in vivo. It is not clear whether the mechanism of this switch involves the recruitment of circulating precursors or the reeducation of cells in situ. In our previous study, we found that E2F1-null (E2F1) mice have enhanced expression of macrophages in the border zone of the skin wound at day 7 post-surgery. However, whether E2F1 mediates the M1-M2 switch during the wound healing process is not known.

Abstract QS30: E2f1 Represses M1 And M2 Macrophages Transformation To Effect Wound Healing Process