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PURPOSE: Murine models are commonly employed to simulate aspects of human adipose physiology. Tremendous advances in our understanding of human obesity and endocrinology have been made possible by comparative studies in mice. However, fat depots — both within and between species — differ dramatically in their transcriptional properties. Understanding the fundamental differences between human and mouse adipose tissue, and thus the inherent limitations of murine models, begins with comparing their basic architecture. This study employs whole tissue mounting and confocal microscopy to characterize the three-dimensional architecture of the mouse inguinal fat pad, and two significant human fat depots, the lower abdomen and gluteofemoral regions.

plastic and reconstructive surgery. global open

Abstract 141: Proximal and Distal Recipient Vessels Are Associated with Equivalent Outcomes in Lower Extremity Trauma Free Flap Reconstruction: A 312 Patient Series and Systematic Review