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METHODS: We utilized a novel, rat forelimb chronic denervation (CD) model to assess the effects of PCL conduits on: a) improving nerve regeneration; and b) improving upper extremity function. Three groups of rats were examined: (1) Group-1 (n = 5) underwent 8 weeks of median nerve CD injury followed by repair with no conduit; (2) Group-2 (experimental, n = 5) underwent 8 weeks of median nerve CD followed by repair and PCL nerve conduit wrapping of the nerve co-aptation site; (3) Group-3 animals (n = 5) were naïve controls. All animals underwent nerve conduction studies on weeks 12 post-repair. All animals also underwent weekly muscle functional testing. At weeks 14 post-repair, the median nerve and flexor muscles were harvested for nerve histomorphometry and muscle weight. To enable the assessment of scarring at the nerve repair site, nerve samples were stained for collagen using direct red 80 sirius red stain. A student t-test was used to evaluate for statistical significance.

plastic and reconstructive surgery. global open

Abstract 129: The Osseointegrated Neural Interface (ONI): A Rabbit Model for Chronic Peripheral Nerve Interfacing in Bone with Percutaneous Osseointegrated Connectors