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PURPOSE: Royal jelly is the well-known queen-maker for the honey bee Apis mellifera, and has documented crossspecies effects on longevity, fertility, and regeneration in mammals. Given larger body size and shorter developmental times in honey bee queens despite genetic similarity to workers, we reasoned that royal jelly may impact stem cell function. Here we show, for the first time, stemness maintenance activities in mouse embryonic stem cells and enhanced wound healing in dorsal mouse wounds.

Abstract 108: Maintenance of Mammalian Stem Cell States and Enhanced Wound Healing by Honey Bee Royal Jelly