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BACKGROUND AND OBJECTIVE: Non-healing wounds are a major cause of morbidity and mortality in diabetic patients. Recently, we have reported the novelty of endothelial progenitor cell (EPC) therapy with serum free ex vivo expansion system called Quantity and Quality Culture System (QQc) using peripheral blood mononuclear cells (PbMNC) as non-invasive and effective new generation cell therapy. After demonstrating high vasculogenic and wound healing potential of this technology with murine and porcine animals, thus obtaining permission under the law of regenerative therapy in Japan, we have begun enrolling diabetic patients with chronic wounds in a prospective phase I/ II clinical trial. The objective of this study is to investigate the safety and efficacy of QQ cultured PbMNC on diabetic non-healing wounds.

plastic and reconstructive surgery. global open

Abstract 05: Efficacy of Phase 1 Clinical Trial of Autologous Quality and Quantity Cultured Vascular and Tissue Regenerative Cell Therapy for Diabetic Patients with Chronic Non Healing Ulcer