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PURPOSE: Regenerative Peripheral Nerve Interfaces (RPNIs) can be used to treat symptomatic end neuromas that develop after major limb amputation. Symptomatic neuromas occur in approximately 30–40% of individuals after limb loss and phantom limb pain affects 70–95% of these patients. We investigate the potential of prophylactic RPNIs to prevent neuroma formation and to mitigate the experience of phantom limb pain. Furthermore, we examine the potential complications resulting from the addition of prophylactic RPNIs to major limb amputation surgery.

Abstract P27: Macrophage Recruitment and Activation to Skeletal Muscle after Acute Nerve Injury