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PURPOSE: Impaired wound healing is a serious complication and impacts patient’s quality of life adversely. Among extracellular matrix (ECM) molecules, hyaluronan (HA) has been suggested to play a critical role in all phases of wound healing as it modulates cell behavior including adhesion, migration, proliferation, metabolism and differentiation. HA is produced by 3 distinct hyaluronan synthesis (Has) and exists in varying sizes. It is widely accepted that large molecular weight HA is involved in structural and anti-inflammatory functions, whereas small molecular weight HA is angiogenetic and pro-inflammatory.

Abstract 95: Inhibition of Scleraxis Signaling Provides a Target to Reduce Mesenchymal Cell Inflammation During Wound Healing