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PURPOSE: The achievement of tolerance induction in Vascularized composite allografts (VCA) could potentially enhance the quality of life for patients with severe facial or extremity injuries while avoiding the risk of immunosuppression. The achievement of tolerance would help transitioning VCA from an experimental to a routine practice worldwide. The purpose of this study was to investigate strategies for tolerance induction in a large animal model and to assess whether current VCA recipients could potentially be weaned off of immunosuppression while maintaining their intact graft using only a co-stimulation blockade agent.

Abstract 46: Whole Eye Transplantation in the Rodent: Long-Term Survival and Effects on the Unoperated Partner Eye