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Thrombophilia is the increased tendency to form thrombi, often silent, usually due to genetic mutations. Venous thrombosis has an incidence of 0.1% in the general adult population. Deep vein thrombosis (DVT) with pulmonary emboli (PE), collectively called venous thromboembolism (VTE), can be fatal in up to 25% of patients with PE. Case review of two brothers with both familial multiple lipomatosis 4,5 and personal and family history of multiple DVTs and PEs questioned whether multiple lipomas and venous thrombosis are associated. Thrombophilia is unsuspected unless abnormal clotting occurs. Multiple lipomas, if correlated, would be a first physical finding, other than venous stasis pathology, representing an external marker for VTE risk.

Abstract: Deep Vein Thrombosis Risk - First External Physical Marker - Multiple Lipomas Associated with Thrombophilia