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67. Ness TJ, Gebhart GF: Visceral pain: A review of experimental studies. Pain 1990; 41:167–234 68. Aubrun F, Langeron O, Quesnel C, Coriat P, Riou B: Relationships between measurement of pain using visual analog score and morphine requirements during postoperative intravenous morphine titration. ANESTHESIOLOGY 2003; 98:1415–21 69. Spencer CC, Su Z, Donnelly P, Marchini J: Designing genome-wide association studies: Sample size, power, imputation, and the choice of genotyping chip. PLoS Genet 2009; 5:e1000477 70. Edwards RR, Fillingim RB, Ness TJ: Age-related differences in endogenous pain modulation: A comparison of diffuse noxious inhibitory controls in healthy older and younger adults. Pain 2003; 101:155–65 71. Fillingim RB, Gear RW: Sex differences in opioid analgesia: Clinical and experimental findings. Eur J Pain 2004; 8:413–25 72. Gear RW, Miaskowski C, Heller PH, Paul SM, Gordon NC, Levine JD: Benzodiazepine mediated antagonism of opioid analgesia. Pain 1997; 71:25–9 73. Maund E, McDaid C, Rice S, Wright K, Jenkins B, Woolacott N: Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs for the reduction in morphinerelated side-effects after major surgery: A systematic review. Br J Anaesth 2011; 106:292–7 74. Oertel BG, Doehring A, Roskam B, Kettner M, Hackmann N, Ferreirós N, Schmidt PH, Lötsch J: Genetic-epigenetic interaction modulates μ-opioid receptor regulation. Hum Mol Genet 2012; 21:4751–60

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