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challenge in humans. Neuroimage 2004; 22:637–44 11. Eger EI II, Tang M, Liao M, Laster MJ, Solt K, Flood P, Jenkins A, Raines D, Hendrickx JF, Shafer SL, Yasumasa T, Sonner JM: Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats. Anesth Analg 2008; 107:479–85 12. Eger EI II, Raines DE, Shafer SL, Hemmings HC Jr, Sonner JM: Is a new paradigm needed to explain how inhaled anesthetics produce immobility? Anesth Analg 2008; 107:832–48 13. Shafer SL, Hendrickx JF, Flood P, Sonner J, Eger EI II: Additivity versus synergy: A theoretical analysis of implications for anesthetic mechanisms. Anesth Analg 2008; 107:507–24. 14. Hendrickx JF, Eger EI II, Sonner JM, Shafer SL: Is synergy the rule? A review of anesthetic interactions producing hypnosis and immobility. Anesth Analg 2008; 107:494–506 15. Cheong E, Lee S, Choi BJ, Sun M, Lee CJ, Shin HS: Tuning thalamic firing modes via simultaneous modulation of Tand L-type Ca2 channels controls pain sensory gating in the thalamus. J Neurosci 2008; 28:13331–40 16. Franks NP: General anaesthesia: From molecular targets to neuronal pathways of sleep and arousal. Nat Rev Neurosci 2008; 9:370–86

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