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The subcutaneous site has been regarded as a potential site for a bioartificial pancreas. Transplantation of islets, encapsulated by the development of diverse biocompatible materials and structural designs, can reverse hyperglycemia in diabetic recipients.

REVERSAL OF DIABETES IN MICE BY XENOTRANSPLANTATION OF A BIOARTIFICIAL PANCREAS IN A PREVASCULARIZED SUBCUTANEOUS SITE1