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In rodents, CsA has been shown to affect T-cell development, giving rise to an abnormal production of mature T cells and the absence of many T-cell subsets as well as to autoimmunity. Surprisingly, only a few studies investigated the effect of the immunosuppressive drug on the immune system of the human fetus.

IMMUNOLOGIC EVALUATION DURING THE FIRST YEAR OF LIFE OF INFANTS BORN TO CYCLOSPORINE-TREATED FEMALE KIDNEY TRANSPLANT RECIPIENTS