English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Binding sites for rat atrial natriuretic peptide (6–33) were quantified by incubation of brain sections with (3-[125I]iodotyrosyl28) rat atrial natriuretic peptide (6–33), followed by autoradiography with computerized microdensitometry. Spontaneously hypertensive rats present lower numbers and lower affinity of binding sites than normotensive controls, Wistar-Kyoto rats, in the subfornical organ (binding capacity 61.7 ± 8.9 and 124.3 ± 10.7 fmol/mg protein; affinity constant 4.25 ± 0.55 and 11.10 ± 1.67 × 109 M−2, respectively). In the choroid plexus, hypertensive rats have lower numbers of sites than normotensive rats (binding capacity 72.7 ± 10.5 and 173.6 ± 22.8 fmol/mg protein, respectively), but there was no difference in the binding affinity (affinity constant 6.28 ± 0.82 and 7.60 ± 2.06 × 109 M−1, respectively). Our results suggest that discretely localized brain binding sites for rat atrial natriuretic peptide (6–33) may have a physiological function in genetically hypertensive rats.

Decreased Number and Affinity of Rat Atrial Natriuretic Peptide (6–33) Binding Sites in the Subfornical Organ of Spontaneously Hypertensive Rats