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Y. Vandenplas ([E~) B. Hauser C. Van den Borre 9 C. Clybouw T. Mahler S. Hachimi-ldrissi L. Deraeve A. Malfroot 9 I. Dab Academic Children's Hospital, Free University of Brussels, Laarbeeklaan 101, B-1090 Brussels, Belgium Tel.: 00.32.2.477.57.80 Fax: 00.32.2.478.57.83 Abs t rac t At the age of 5 years, the prevalence of atopic manifestations was analysed in 58 formula-fed "at risk" infants because of a history of atopic disease in at least two first degree relatives. Infants were randomly assigned to receive either a partial whey-hydrolysate formula (n: 28) or a regular cow's milk formula (n: 30) during the first 6 months of life; thereafter, feeding was unrestricted. Only non-breastfed infants were included. The groups did not differ in risk factors or in known confounding factors possibly influencing the incidence of manifestations suggestive of atopic disease. At 6 months, the prevalence of cow's milk protein (CMP) sensitivity was significantly decreased in the hydrolysate group (7% versus 43%; P: 0.002). At the age of 12 (21% versus 53%; P: 0.029), 36 (25% versus 57%; P: 0.018) and 60 months (29% versus 60%; P: 0.016) there was still a significant difference in the number of atopic manifestations, if calculated cumulatively. There was no difference between the groups if only the new cases after the age of 6 months were considered. Eczema was less frequent in the whey-hydrolysate group, but only during the I st year of life, suggesting a decreased prevalence of CMP sensitivity. During the first 6 months, diarrhoea of non-infectious origin occurred in 8/30 infants (27%) of the adapted formula group, and in no infant in the hydrolysate group. "Colic as single manifestation" was considered of "allergic" origin in 1/28 infants in the hydrolysate group, and in 4/30 infants in the adapted formula group. If gastro-intestinal symptoms such as "diarrhoea and colic as single manifestation" are not considered, the number of infants with CMP sensitivity remains only significant for the first 6 months (P: 0.004). At 12, 36 and 60 months, differences are not significant (0.106, 0.116 and 0.07, respectively). The results of this study support the hypothesis that allergy prevention is antigen specific.

128 THE LONG-TERM EFFECT OF A PARTIAL WHEY HYDROLYSATE FORMULA ON THE PROPHYLAXIS OF ATOPIC DISEASE