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The effect of preload on myofilament Ca 2+ sensitivity was examined using α-toxin permeabilization and fura-2 fluorometry in rabbit cerebral arteries. The [Ca 2+ ]i-force curves shifted leftward at a high preload, with a decrease in median effective concentration of Ca 2+ in the permeabilized artery. In the fura-2-loaded artery, the preload modulated the force without affecting [Ca 2+ ]i levels during K + depolarization, and a high preload moved the [Ca 2+ ]i-force curve upward and to the left. It is thus concluded that the preload regulates the Ca 2+ sensitivity of the myofilament and, therefore, may play a role in the regulation of cerebral arterial tonus and blood flow.

Resting Load and Modulation of the Myofilament Ca2+Sensitivity in Rabbit Cerebral Arteries

Resting Load and Modulation of the Myofilament Ca²⁺Sensitivity in Rabbit Cerebral Arteries