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THE use of plastic tissue adhesives to provide hemostasis, to seal raw surfaces, to simplify the anastomosis of various tubular structures and to reinforce insecure suture lines has been the object of intense investigation. These studies have led to wide differences of opinion among investigators as to the advisability of clinical use of adhesives. Because an occasional situation develops in which there is need for such substances in cardiovascular surgery, it was believed that additional investigation of the myocardial response to the application of these agents was warranted. These experiments compare the effect of methyl-2-cyanoacrylate with butyl-cyanoacrylate applied to the atrial and ventricular myocardium of dogs.

Myocardial Response to the Application of Tissue Adhesives. Comparison of Methyl-2-cyanoacrylate and Butyl-cyanoacrylate