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PRAcTIcALLY all surgeons have occasionally observed a rapid spread and growth of carcinoma shortly after an unsuccessful attempt to remove all of a carcinoma. This observation and experimental data accumulating in our laboratory recently, while conducting experiments on the "takes" of Walker 256 carcinosarcoma cells, have stimulated us to design an experiment to test out the hypothesis that operative stress might at times result in a decreased resistance of the host to cancer cells.

Role of Operative Stress on the Resistance of the Experimental Animal to Inoculated Cancer Cells