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How WOUNDS HEAL has been a concern of surgeons since the dawn of medicine. In the beginning it was thought that "humors" within the body affected repair as evidenced by the statement attributed to Paracelsus, "There is an inborn balsam which heals wounds." This notion of a humoral factor in healing dominated surgical writing until Virchow's studies in cellular pathology provided a scientific background for the investigation of injury and repair. From that time until the present surgeons have looked upon wound healing largely as a cellular phenomenon, first in terms of histology and later, following the classic

Wound Healing. A New Perspective with Particular Reference to Ascorbic Acid Deficiency