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N-methyl-d-aspartate (NMDA) receptor antagonists are neuroprotective in animal models of cerebral ischemia, but adverse cardiovascular and neurobehavioral effects have precluded their clinical use. The authors present the neuroprotective, anesthetic, and cardiovascular effects of a novel NMDA antagonist, CNS 5161A.

Neuroprotective, Anesthetic, and Cardiovascular Effects of the NMDA Antagonist, CNS 5161A, in Isoflurane-anesthetized Lambs