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Clonidine, an alpha 2-adrenergic agonist, has been studied as an adjunct or alternative to spinal opioids in the management of moderate to severe pain. This study examined the relative effects of clonidine on efferent spontaneous sympathetic activity and afferent A delta and C fiber-mediated somatosympathetic responses.

Clonidine Has Comparable Effects on Spontaneous Sympathetic Activity and Afferent Aδ– and C-Fiber-mediated Somatosympathetic Reflexes in Dogs