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It is known that peripheral nerve injury induces time-dependent changes in dorsal horn function. The current study investigated the time dependency of the effects of intrathecal morphine and MK-801, an N-methyl-D-aspartate antagonist, on the thermal hyperesthesia evoked by unilateral constriction injury to the sciatic nerve in the rat.

anesthesiology

Time-dependent Effect of Morphine and Time-independent Effect of MK-801, an NMDA Antagonist, on the Thermal Hyperesthesia Induced by Unilateral Constriction Injury to the Sciatic Nerve in the Rat