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While flumazenil reverses benzodiazepine-induced sedation, its ability to antagonize the ventilatory depressant effects of benzodiazepines has not been fully established. A randomized, double-blind study was conducted to determine whether flumazenil effectively reverses midazolam-induced depression of the hypoxic ventilatory response.

The Effect of Flumazenil on Midazolam-induced Depression of the Ventilatory Response to Hypoxia during Isohypercarbia