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The parenteral administration of potent analgesic agents, most commonly of the narcotic group, remains the principal form of treatment for postoperative pain. However, narcotic analgesics may produce undesirable side effects: drowsiness, emesis and respiratory depression. Moreover, their use is subject to legislative restrictions. Hitherto, the availability of parenteral preparations of non-narcotic analgesics has been limited. However, it has been suggested that a parenteral salicylate preparation, lysine acetyl salicylate (LAS), in a dose of 1.8 g (equivalent to acetyl salicylate 1 g), can provide analgesia equivalent to that provided by morphine 10 mg (Kweekel-De Vries et al., 1974). This study reports on a comparison of the analgesic effect of a continuous i.v. infusion of LAS with that of morphine (administered similarly) for the relief of pain following thoracotomy.

A COMPARISON OF INFUSIONS OF MORPHINE AND LYSINE ACETYL SALICYLATE FOR THE RELIEF OF PAIN FOLLOWING THORACIC SURGERY