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THE PRESENT COMMUNICATION deals with experiments showing that the early mortality following severe thermal injury is profoundly influenced by the type of sedation and anesthesia u,sed, In the first pa,per of this series1 the combination of nembutal and morphine used produced a good anesthesia during the injury itself, as well as -a fairly prolonged sedation afterwards. Following the publication of this data, Dr. Alfred Blalock wrote that he had repeated these experiments and had observed a much lower mortality; indeed, only two deaths occurred under 24 hours in a series of I2 experiments in which a thermal stimulus of 850 to 9o0 centigrade for 5 to I5 seconds, up to the axilla, was employed. With a similar degree of injury, our mortality was IOO per cent. The fact that he used a smaller dose of morphine without nembutal -plus a short ether anesthesia during the burn stimulus suggested that the pronounced difference in mortality might perhaps be due to the type of anesthesia used. In order to study this supposition, a series of experiments were carried out in which a somewhat more severe burn stimulus (immersion up to the axilla at IOO0 centigrade for IO seconds) was employed in a series of ten experiments each; various doses of morphine in combination with nembutal or ether were used in each group. Experimental Findings.-Table I records the essential findings, which indicate clearly the deleterious effect of morphine and nembutal, particularly the former, on the 24-hour mortality.

The Influence of Ether, Morphine and Nembutal on Mortality in Experimental Burns