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The proliferative activity of vascular cells and the number of macrophages were studied in corpora lutea of cycling and pregnant rats after prolactin (PRL) administration or depletion with the dopaminergic agonist CB154. Pregnant rats showed a higher proliferative activity of the vascular cells in newly formed corpora lutea than did cycling rats in metestrus. When cycling rats were treated with PRL, the proliferative activity was equivalent to that of pregnant rats. Treatment of pregnant rats with CB154 decreased the proliferative activity of vascular cells to the level in cycling rats. Otherwise, the proliferative activity was not modified in cycling rats after CB154 treatment. This indicates that the increase in the proliferative activity of vascular cells in the corpus luteum of pregnancy was due to the twice-daily PRL surges induced by mating. Treatment of cycling rats with CB154 decreased the number of macrophages in both newly formed and regressing corpora lutea, whereas PRL treatment increased the number of macrophages in regressing corpora lutea. In pregnant rats, treatment with CB154 decreased the number of macrophages in both newly formed and regressing corpora lutea. These results suggest that both the preovulatory and the twice-daily PRL surges regulate the macrophage population in newly formed and regressing corpora lutea.

biology of reproduction

Role of Prolactin in the Regulation of Macrophages and in the Proliferative Activity of Vascular Cells in Newly Formed and Regressing Rat Corpora Lutea1