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Uterine growth, cell proliferation, and endometrial expression of the c-fos proto-oncogene were evaluated for nonpregnant ewes (n = 6 ewes per day) on Days 0 (estrus), 2, 4, 8, 12, and 15 of the estrous cycle. Fresh and dry weights of uterine horns decreased (p &lt; 0.01) linearly from Days 0 to 8 and then remained similar from Day 8 through Day 15. Tissue water content (1 - [dry weight/fresh weight]) was greater on Day 0 (p &lt; 0.01) than on Days 2, 4, and 8, and the latter values were greater (p &lt; 0.01) than on Days 12 and 15. DNA content was similar on Days 0, 2, 4, 8, and 15 but increased (p &lt; 0.01) on Day 12. Although DNA content was greatest on Day 12, the ratios of RNA to DNA and of protein to DNA were least (p &lt; 0.01) on that day. Thus, changes in uterine fresh weight were associated primarily with changes in tissue hypertrophy (RNA:DNA and protein:DNA ratios) and water content. In addition, changes in uterine fresh weight were associated with changes in the ratio of estradiol to progesterone in systemic blood, which was greatest (p &lt; 0.01) on Days 0 and 2, decreased (p &lt; 0.01) from Day 2 to Day 8, remained low through Day 12, and then was elevated again (p &lt; 0.01) on Day 15. Moreover, compartmentalized changes in endometrial cell proliferation (labeling index [LI]; percentage of cells exhibiting nuclear incorporation of bromodeoxyuridine, a thymidine analogue) also were associated with the changes in fresh weight. The epithelium of the uterine lumen and luminal glands exhibited the greatest changes in rate of cell proliferation and accounted for most of the changes in LI seen across days of the estrous cycle. Endometrial expression of c-fos mRNA and protein also reflected changes in uterine weight and the systemic estradiol:progesterone ratio. The level of c-fos mRNA was greatest at estrus, low on Days 2-8, and elevated slightly on Days 12 and 15; Fos protein was greatest on Days 0 through 4, least on Day 8, and intermediate on Days 12 and 15. Characterization of uterine growth, cell proliferation, and c-fos expression throughout the estrous cycle will provide a foundation for future studies of gene expression regulating growth of the nonpregnant uterus.

Uterine Growth, Cell Proliferation, and C-fos Proto-Oncogene Expression Throughout the Estrous Cycle in Ewes1