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Hypothalamic enzymatic luteinizing hormone-releasing hormone (LHRH)-degrading activity (LHRH-DA) may play a physiologic role in the neuroendocrine control of LHRH in mammals. The present study analyzes the existence and possible physiologic role of LHRH-DA in birds. The LHRH content in discrete hypothalamic samples of laying and nonlaying hens was correlated to their LHRH-DA. Degrading activity was assessed by high-performance liquid chromatography (HPLC) of chicken LHRH and of its degradation fragments. Luteinizing hormone-releasing hormone content was estimated by radioimmunoassay. Luteinizing hormone-releasing hormone content of discrete medial preoptic, infundibulum, and arcuate samples, as well as serum LH and progesterone levels, were higher (P less than 0.05) in laying than in nonlaying hens. The LHRH content of these hypothalamic areas was also higher (P less than 0.05) than those of immediately adjacent areas, in both animal groups. Luteinizing hormone-releasing hormone-degrading activity, which generates LHRH1-5 as the main degradation fragment, was higher (P less than 0.01) in the infundibulum of laying than in nonlaying hens. It was also higher (P less than 0.01) in samples from the infundibulum and medial preoptic area than in immediately adjacent lateral samples. Finally, LHRH-DA, showing a similar HPLC profile of degradation fragments, was also present in areas of low or undetectable LHRH content.(ABSTRACT TRUNCATED AT 250 WORDS)

biology of reproduction

Discrete Hypothalamic Distribution of Luteinizing Hormone-Releasing Hormone (LHRH) Content and of LHRH-Degrading Activity in Laying and Nonlaying Hens1