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This study describes the cardiac size and function of patients with sickle  cell anaemia, in Segipe, Brazil, and its association to the clinical severity,  duration of illness and haemoglobin levels. Heart measurements were obtained  by echocardiography from 38 children and adolescents and compared to international  reference values. Sickle cell patients had increased left atrial and ventricular  dimensions in systole and an increased end diastolic septal and left ventricular  free wall thickness. These findings correlated with age. There were no abnormalities  in the ejection or shortening fractions. These results suggest early haemodynamic  changes with progressive cardiac chamber dilation and diastolic dysfunction  that become increasingly abnormal with growth.

Echocardiographic Characteristics of Patients with Sickle Cell Anaemia in Sergipe, Brazil