English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the zaia usage as premium feature

ZAIA

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the access of premium content as premium feature

Premium Content

Zendy Tools

Zendy Open

Snakebite is considered as one of the acute severe medical problems across the world. Snake venoms composed of various group of toxins, enzymes and non-toxic enzymes. Phospholipases A 2  present in  Naja naja  snake venom plays a significant role in lipid signalling and contributes to different inflammation in the human body.  Dryopteris cochleata  rhizomes have antioxidant, antimicrobial property and used to treat lesions, gonorrhoea, sores, muscular pain, rheumatic and also useful in dog and snake bites. In this study, Indian male fern  D. cochleata  rhizomes have been used for green synthesis of silver nanoparticles with the aim to increase the bioactivity of plant extract and to evaluate  N. naja  snake venom inhibition activity of prepared nanoparticles. Green synthesized nanoparticles were characterized with the help of ultraviolet–visible spectroscopy, Fourier-transform infrared spectroscopy, X-ray powder diffraction and atomic force microscopy.  Naja naja  venom inhibition activity of nanoparticles was performed using  in vitro  phospholipases A 2  assay and tissue damage activity. The results showed that surface plasmon resonance maxima peaks of nanoparticles were observed at 424 nm. Average particle size was around 35 nm, with a spherical shape. Neutralization results exhibited that synthesized silver nanoparticles from  D. cochleata  decreased percentage of tissue damage, resulting in significant inhibition of phospholipase A 2  and  N. naja  snake venom. Results concluded that green synthesized silver nanoparticles from  D. cochleata  rhizome neutralize  N. naja  snake venom activity.

toxicology research

Green synthesis of silver nanoparticles using Indian male fern ( Dryopteris Cochleata ), operational parameters, characterization and bioactivity on  Naja naja  venom neutralization