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The objective of the study was to examine how  l -citrulline supplementation to ewes during mid-gestation influences placental activity, placental blood flow, lamb body weight, and carcass characteristics. Two studies were completed. A pharmacokinetic study to compare circulating plasma amino acid concentrations after a single intravenous injection of 155 µmol/kg BW  l -citrulline or after an isonitrogenous amount of  l -alanine (control; 465 µmol/kg BW). Increases ( P  &lt; 0.05) in circulating citrulline concentrations were detected for 8 h after  l -citrulline injection versus the control. Similarly, increases ( P  &lt; 0.05) in circulating arginine concentrations were detected for 24 h after  l -citrulline treatment. The second study used 12 ewes with twin pregnancies. Daily intravenous injections of either  l -citrulline or  l -alanine were administered for 39 d from d 42–45 to 81–84 of gestation. Ewes were limit-fed at 85% daily energy requirements during the injection period. A decrease ( P  &lt; 0.0001) in body weight was observed in both treatment groups during this period. No treatment differences were observed in circulating pregnancy-specific protein B concentrations or placental blood flow during the treatment and post-treatment gestational period. No treatment differences were observed in lamb survival nor in lamb birth, weaning and slaughter weights. Treatment did not influence lamb carcass composition or organ weights. However, there was a tendency ( P  = 0.10) for an increase in antral follicle numbers in ovaries from ewe lambs derived from ewes treated with  l -citrulline. In summary, a daily  l -citrulline injection increased both circulating citrulline and arginine concentrations in ewes, but daily  l -citrulline injections during mid-gestation did not produce any detectable changes in placental activity and blood flow, neonatal and postnatal lamb development, and lamb carcass composition at slaughter. In conclusion, no benefits in placental function and lamb development were observed after providing  l -citrulline during mid-gestation in ewes exposed to a mild energy restriction, but there was an indication that follicle numbers in ewe lambs were positively influenced by  l -citrulline treatment during fetal development.

translational animal science

Effects of mid-gestational <scp>l</scp>-citrulline supplementation to twin-bearing ewes on umbilical blood flow, placental development, and lamb production traits

Effects of mid-gestational l-citrulline supplementation to twin-bearing ewes on umbilical blood flow, placental development, and lamb production traits