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Background Obstructive sleep apnoea (OSA) is highly prevalent in Australia with significant health and economic impacts. OSA severity as measured by Apnoea Hypopnoea Index (AHI) does not reliably predict symptom burden as measured by questionnaires such as the Epworth Sleepiness Scale (ESS) or Functional Outcomes of Sleep Questionnaire (FOSQ). Our hypothesis is that utilising the standardised, scenario-agnostic, evidence-based Patient-Reported Outcomes Information System (PROMIS) questionnaires would yield better clinical utility. The primary aim was to validate PROMIS questionnaires in detecting symptom burden of OSA and its relationship to AHI. Secondary outcomes were to investigate the relationship between PROMIS questionnaires and other commonly used measures of sleep impairment and disturbance, and the relationship between PROMIS questionnaires and surrogate markers of sleep impairment on a Polysomnogram. Methods Analysis of prospectively collected data from 122 adult patients referred to an Australian University and Tertiary Hospital associated sleep apnoea clinic. All adult patients who completed extensive pre-assessment questionnaires and subsequently underwent polysomnography following clinician review were included in this study. Questionnaires included: PROMIS Sleep Disturbance, Sleep Related Impairment and Cognitive Function-Abilities questionnaires, FOSQ, ESS, Insomnia Severity Index (ISI) and Hospital Anxiety and Depression Scale (HADS). Progress to date Data collected for all 122 participants. Preliminary analysis currently underway. Intended outcome and impact: Examine utility of the novel PROMIS scales in measuring symptom burden in patients referred for suspected OSA and its relationship to AHI. Investigate the relationship between PROMIS scales, surrogate markers of sleep impairment and other validated sleep disorder questionnaires.

O044 PROMISing questionnaires to measure sleep disturbance and impairment