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The effect of increased cognitive load especially under duress has been known to affect brain rhythms in humans. However, this effect has been shown primarily in the awake brain; the effect of stressful cognitive load on sleep rhythms is yet unclear. We leveraged a unique opportunity to understand the effect of cognitive load under laboratory stress on sleep spindles and slow oscillations that are hallmark rhythms of NREM sleep. Methods Cortical 6-channel EEG nap data were collected from 45 subjects over two separate days: after a control session without laboratory stressors and after an experimental session in which they underwent fear condiitoning and negative-emotional-image viewing sessions. We detected sleep spindles (11-13Hz over frontal regions and 13-16Hz over centroposterior regions) and slow oscillations (0.16–1.25Hz oscillations) as discrete events at each of the six electrodes, and staged them by the sleep hypnogram. We evaluated the spindle rate in N2 sleep and the proportion of slow oscillations nested with a spindle in N3 sleep. Results Over all 6 EEG electrodes, N2 spindle rates increased on average by 14% in the experimental session compared to the control session (mixed-effect models p&amp;lt;0.001). In addition, over all 6 electrodes, the proportion of slow oscillations in N3 nested with a spindle increased by 2.3% in the experimental session compared to the control session (mixed effect model, p=0.005). Conclusion We show for the first time how increased cognitive load under stressful laboratory conditions affects sleep rhythms. Such an increased response in sleep might correspond to a continued emotional response due to the cognitive load under duress. Ongoing work seeks to tie these findings to possible emotional memory consolidation. Support (if any) VA Career Development Award to Dr. Richards (5IK2CX000871-05)

048 Increased Cognitive Load Under Stress Modulates Sleep Spindles and Slow Oscillations in a Sleep-Stage Dependent Manner