Open AccessCircadian Rhythms of Melatonin, Cortisol, and Clock Gene Expression During Simulated Night Shift Work
Author(s) -
Francine O. James,
Nicolas Cermakian,
Diane B. Boivin
Publication year - 2007
Publication title -
sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.222
H-Index - 207
eISSN - 1550-9109
pISSN - 0161-8105
DOI - 10.1093/sleep/30.11.1427
Subject(s) - melatonin , circadian rhythm , shift work , clock , rhythm , endocrinology , circadian clock , medicine , chronobiology , sleep (system call) , dark therapy , gene expression , biology , gene , neuroscience , genetics , computer science , operating system
The synchronization of peripheral circadian oscillators in humans living on atypical sleep/wake schedules is largely unknown. In this night shift work simulation, we evaluate clock gene expression in peripheral blood mononuclear cells (PBMCs) relative to reliable markers of the central circadian pacemaker.
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