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The regulation of arousal and pupillary functions may be intimately linked via activity in the nucleus locus coeruleus. In this preliminary study, we tested the validity of the gradual pupillary miosis during 5 minutes in darkness, as a quantitative physiologic index of the arousal state of the brain.

sleep

Pupil Miosis Within 5 Minutes in Darkness Is a Valid and Sensitive Quantitative Measure of Alertness: Application in Daytime Sleepiness Associated With Sleep Apnea