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Semantic memory (SM) impairments are a core feature of schizophrenia and are present along the psychosis continuum. It is, however, unclear whether the degree of SM impairments vary along this continuum and if demographic and clinical factors affect impairment severity. This study performed meta-analyses of category fluency task performance (a task commonly used to assess SM) in 4 groups along the schizophrenia continuum: high schizotypes (HSZT), first-degree relatives (FDR), recent-onset patients (≤2 y; ROP) and chronic patients (CSZ). Electronic databases were searched for relevant studies published up to October 2019 resulting in the inclusion of 48 articles. The main analyses assessed fluency productivity scores in 2978 schizophrenia spectrum disorder patients, 340 first-degree relatives of schizophrenia spectrum disorder patients, and 3204 healthy controls. Further analyses assessed errors, mean cluster size, and switching data that were available in the CSZ group only. Results revealed significant impairments in fluency productivity were present in the FDR, ROP, and CSZ groups relative to healthy controls, but not in HSZT. In the CSZ group, significant differences relative to healthy controls were also observed in non-perseverative errors, mean cluster size, and number of switches. The findings collectively suggest that SM deficits are present at each stage of the continuum and are exacerbated post-illness onset. They also support the centrality of SM impairments in schizophrenia and most elevated risk groups. Future studies with more diverse measures of SM function are needed to replicate and extend this research.

Semantic Memory Impairment Across the Schizophrenia Continuum: A Meta-Analysis of Category Fluency Performance