English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Despite recent advances, there is still a major need for prediction of treatment success in schizophrenia. Cortical thickness measures are relatively easy to obtain and may provide biomarker candidates. Here, we tested a set of candidate brain regions as predictors of treatment response in first episode schizophrenia and in two independent schizophrenia cohorts. Regions included the precuneus, inferior parietal gyrus, superior temporal gyrus, parahippocampal gyrus, anterior cingulate, inferior frontal gyrus, insula, lateral and medial orbitofrontal cortex, and occipital cortex.    Methods  In the discovery cohort, we used the whole sample of patients to estimate individual response slopes using Empirical Bayes, 36 of which had cortical thickness measurements at baseline. Patients were scanned aprior to treatment with either risperidone or aripiprazole. Symptoms were assessed with the Brief Psychiatric Rating Scale at baseline and over the course of up to 52 weeks. Cortical thickness in regions of interest were examined via magnetic resonance imaging and used as predictors of individual treatment response, defined as individual response slope.    Results  Parahippocampal thickness at baseline predicted the individual response to treatment (P < 0.05, Bonferroni-corrected). This was replicated in two independent schizophrenia cohorts including a recent onset cohort (N = 33) and a sample of chronic schizophrenia patients (N = 52), respectively. The overall effect was quantified with an internal meta-analysis (β = 0.4, 95% CI [0.24; 0.56]; z = 4.84, P < 0.001).    Discussion  Parahippocampal thickness may be a promising marker of treatment success both at the early and the chronic stage of schizophrenia.

S20. PARAHIPPOCAMPAL THICKNESS PREDICTS TREATMENT IMPROVEMENT IN EARLY AND CHRONIC SCHIZOPHRENIA