Open AccessNeurobiological Commonalities and Distinctions Among Three Major Psychiatric Diagnostic Categories: A Structural MRI Study
Author(s) -
Miao Chang,
Fay Y. Womer,
E. Kale Edmiston,
Chuan Bai,
Qian Zhou,
Xiaowei Jiang,
Shengnan Wei,
Yange Wei,
Yuting Ye,
Haiyan Huang,
Yong He,
Ke Xu,
Yanqing Tang,
Fei Wang
Publication year - 2017
Publication title -
schizophrenia bulletin
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.823
H-Index - 190
eISSN - 1745-1701
pISSN - 0586-7614
DOI - 10.1093/schbul/sbx028
Subject(s) - major depressive disorder , white matter , psychology , bipolar disorder , diffusion mri , magnetic resonance imaging , schizophrenia (object oriented programming) , neuroscience , brain size , neuroimaging , psychiatry , medicine , cognition , radiology
Schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) are distinct diagnostic categories in current psychiatric nosology, yet there is increasing evidence for shared clinical and biological features in these disorders. No previous studies have examined brain structural features concurrently in these 3 disorders. The aim of this study was to identify the extent of shared and distinct brain alterations in SZ, BD, and MDD. We examined gray matter (GM) volume and white matter (WM) integrity in a total of 485 individuals (135 with SZ, 86 with BD, 108 with MDD, and 156 healthy controls [HC]) who underwent high-resolution structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) at a single site.
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