Open AccessComparison of the Heritability of Schizophrenia and Endophenotypes in the COGS-1 Family Study
Author(s) -
Gregory A. Light,
Tiffany A. Greenwood,
Neal R. Swerdlow,
Monica E. Calkins,
Robert Freedman,
M. F. Green,
Ruben C. Gur,
Ruben C. Gur,
Laura C. Lazzeroni,
Keith H. Nuechterlein,
Ann Olincy,
Allen D. Radant,
Larry J. Seidman,
L.J. Siever,
Jeremy M. Silverman,
Joyce Sprock,
William S. Stone,
Catherine A. Sugar,
Debby W. Tsuang,
Ming T. Tsuang,
Bruce I. Turetsky,
David Braff
Publication year - 2014
Publication title -
schizophrenia bulletin
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.823
H-Index - 190
eISSN - 1745-1701
pISSN - 0586-7614
DOI - 10.1093/schbul/sbu064
Subject(s) - endophenotype , heritability , schizophrenia (object oriented programming) , psychology , psychiatry , genetics , biology , cognition
Twin and multiplex family studies have established significant heritability for schizophrenia (SZ), often summarized as 81%. The Consortium on the Genetics of Schizophrenia (COGS-1) family study was designed to deconstruct the genetic architecture of SZ using neurocognitive and neurophysiological endophenotypes, for which heritability estimates ranged from 18% to 50% (mean = 30%). This study assessed the heritability of SZ in these families to determine whether there is a "heritability gap" between the diagnosis and related endophenotypes.
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