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Nephrotoxic nephritis (NTN) was induced in male WKY or P2X7 KO (on a WKY background) rats using a single IV injection of nephrotoxic serum. Animals were treated with one of two distinct P2X7 antagonists from day 1 after immunisation and were sacrificed at day 7. Antagonist 1A438079 was administered twice a day by intraperitoneal injection (IP) and based on a previous study using this antagonist in NTN a dose of 275μmol/kg was used. Antagonist 2AZ11657312 was administered twice daily by oral gavage at a dose of 60mg/kg based on information provided by Astra Zeneca. Control animals received equivalent sterile water IP or by oral gavage respectively. Disease severity was assessed at day 7.

214. THE EFFECT OF P2X7 ANTAGONISM ON NEPHROTOXIC NEPHRITIS