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IgG aPL against domain I of β2-glycoprotein I (β2GPI) [anti-DI (aDI)] is associated with the pathogenesis of APS, an autoimmune disease defined by thrombosis and pregnancy morbidity. To date, however, no study has demonstrated direct pathogenicity of IgG aDI in vivo. In this proof-of-concept study, we designed a novel system to affinity purify polyclonal aDI aPL in order to assess its prothrombotic ability in a well-characterized mouse microcirculation model for APS.

rheumatology

Proof-of-concept study demonstrating the pathogenicity of affinity-purified IgG antibodies directed to domain I of 2-glycoprotein I in a mouse model of anti-phospholipid antibody-induced thrombosis