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cell lines induced 5-10 fold greater expression of the Th17 transcription factor RORgt. Overall a mean of 57.2% of all IL-23Rþ CD4þ T cells expressed KIR3DL2 in SpA patients, compared with 37%, 53.7% and 24.5% of IL-23Rþ CD4þ T cells in HLA-B27healthy controls, HLA-B27þ healthy controls and RA patients respectively. KIR3DL2þ CD4þ T cells comprised a mean of 40% of all OX40-expressing CD4þ T cells in SpA patients compared with 30% and 17% of B27þ and B27controls and 19% of RA controls. KIR3DL2þCD4 T cells also comprised a greater proportion of IL1Rþ and CCR9þ CD4 T cells in SpA patients. By contrast we did not observe changes in the expression of these markers within the KIR3DL2 negative CD4 T cell compartment. Conclusion: Our results support a central role for B27 KIR3DL2 interactions in the development of Th17 immune responses in SpA patients and suggest that the development of reagents that target this interaction could be of therapeutic benefit. Disclosure statement: S.K. has received grants/research support from Arthritis Research UK and NIHR. A.R. has received grants/ research support from NIHR. I.W.-B. has received grants/research support from ConaCyt. H.H. has received grants/research support from JSPS. J.S. has received grants/research support from Arthritis Research UK. H.A.-M. hs received grants/research support from the Welcome Trust. The other author has declared no conflicts of interest.

rheumatology

235. Absence of Association for Ddah1 Polymorphism, Rs17384213, with Scleroderma Renal Crisis Highlights Diversity in Renal Complications of Connective Tissue Disease