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Montopoli M, Finotti P. Angiogenic transforming capacity of IgG purified from plasma of type 1 diabetic patients. J Cell Mol Med 2009;13:1336–47. 4 Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest 1998; 101:273–81. 5 Hendershot L, Bole D, Kohler G, Kearney JF. Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein. J Cell Biol 1987;104:761–7. 6 Bole DG, Hendershot LM, Kearney JF. Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas. J Cell Biol 1986;102:1558–66. 7 Haas IG, Wabl M. Immunoglobulin heavy chain binding protein. Nature 1983;306:387–9. 8 Vanhove M, Usherwood YK, Hendershot LM. Unassembled Ig heavy chains do not cycle from BiP in vivo but require light chains to trigger their release. Immunity 2001;15:105–14. 9 Kaloff CR, Haas IG. Coordination of immunoglobulin chain folding and immunoglobulin chain assembly is essential for the formation of functional IgG. Immunity 1995;2: 629–37. 10 Pollok BA, Anker R, Eldridge P, Hendershot L, Levitt D. Molecular basis of the cell-surface expression of immunoglobulin mu chain without light chain in human B lymphocytes. Proc Natl Acad Sci USA 1987;84:9199–203. 11 Feige MJ, Groscurth S, Marcinowski M et al. An unfolded CH1 domain controls the assembly and secretion of IgG antibodies. Mol Cell 2009;34:569–79. 12 Knarr G, Gething MJ, Modrow S, Buchner J. BiP binding sequences in antibodies. J Biol Chem 1995;270: 27589–94. 13 Pandey JP, Fudenberg HH, Ainsworth SK, Loadholt CB. Autoantibodies in healthy subjects of different age groups. Mech Ageing Dev 1979;10:399–404. 14 Dobrodeeva LK, Sen’kova LV, Liutfalieva GT, Kornienko EB, Prelovskaia IB, Dobrodeev GV. Levels of autoantibodies in healthy subjects. Fiziol Cheloveka 2006; 32:99–107. 15 Arbuckle MR, McClain MT, Rubertone MV et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 2003;349: 1526–33.

rheumatology

Comment on: Efficacy and safety of various repeat treatment dosing regimens of rituximab in patients with active rheumatoid arthritis: results of a Phase III randomized study (MIRROR)