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To investigate whether maintaining the chondrocyte's native pericellular matrix prevents collagen-induced up-regulation of collagenase-3 (MMP-13) and whether integrin α1 (ITGα1) and/or discoidin domain receptor 2 (DDR2) modulate MMP-13 expression and which signalling pathway plays a role in collagen-stimulated MMP-13 expression.

rheumatology

Collagen-induced expression of collagenase-3 by primary chondrocytes is mediated by integrin 1 and discoidin domain receptor 2: a protein kinase C-dependent pathway